You can equip up to five runes at a time - one from each of the five classes. Runes grant powerful bonuses to your creatures, or modify the way certain buffs and debuffs work.
| Name | Description |
| Rao Rune | Your creatures have +10% Attack. |
| Rii Rune | Your creatures deal 35% more damage to Chaos creatures. |
| Rod Rune | Your creatures take 35% less damage from Chaos creatures. |
| Ruh Rune | You gain 25% more Brimstone from battles. |
| Sah Rune | Your creatures' Berserk buffs no longer cause them to take extra damage. |
| Seo Rune | Your creatures' Multistrike buffs now cause them to attack 1 additional time. |
| Tae Rune | Your creatures' Splash buffs now cause them to deal 100% of their attack damage to adjacent enemies. |
| Tur Rune | Enemies' Burn debuffs now cause them to take 100% more damage from this debuff. |
| Uka Rune | Enemies' Stun debuffs now cause them to take 50% more damage. |
| Uyi Rune | Enemies' Vulnerable debuffs now cause them to have a 0% chance to dodge attacks or deal critical damage. |
| Name | Description |
| Vae Rune | Your creatures have +10% Defense. |
| Var Rune | Your creatures deal 35% more damage to Death creatures. |
| Wex Rune | Your creatures take 35% less damage from Death creatures. |
| Xil Rune | You gain 25% more Granite from battles. |
| Xio Rune | Your creatures' Leech buffs now also cause their attacks to steal a buff from the enemy. |
| Yar Rune | Your creatures' Taunt buffs now also cause them to automatically Provoke at the end of their turns. |
| Yun Rune | Enemies' Bleed debuffs now deal damage 2 times at the start of their turns. |
| Zar Rune | Enemies' Blight debuffs now also cause any buffs they gain to be converted to a random debuff instead. |
| Zey Rune | Enemies' Curse debuffs now also cause them to take 25% of your creatures' Intelligence as damage when they attack. |
| Zod Rune | Enemies' Weak debuffs now cause them to be killed when they take damage and their Health falls below 20%. |
| Name | Description |
| Aen Rune | Your creatures have +10% Maximum Health. |
| Aon Rune | Your creatures take 35% less damage from Life creatures. |
| Aru Rune | Your creatures deal 35% more damage to Life creatures. |
| Chi Rune | You gain 25% more Power from battles. |
| Dao Rune | Your creatures' Barrier buffs absorb 30% more damage. |
| Dun Rune | Your creatures' Mend buffs heal 50% more Health. |
| Eda Rune | Your creatures' Protect buffs also have a 25% chance to negate incoming damage. |
| Efu Rune | Your creatures' Shell buffs now also heal them for 30% of their Maximum Health when this buff is removed. |
| Eno Rune | Enemies' Scorn debuffs now also prevent them from defending and provoking. |
| Eri Rune | Enemies' Sleep debuffs have a 50% chance to persist after the enemy takes damage. |
| Name | Description |
| Fen Rune | Your creatures have +10% Speed. |
| Fih Rune | Your creatures deal 35% more damage to Nature creatures. |
| Ime Rune | Your creatures take 35% less damage from Nature creatures. |
| Inu Rune | You gain 25% more Crystal from battles. |
| Ith Rune | Your creatures' Critical buffs now also increase the damage they deal with spells by 30%. |
| Jih Rune | Your creatures' Grace buffs now also reduces the damage they take from spells by 30%. |
| Kai Rune | Enemies' Blind debuffs now also have a 30% chance to make them fail to cast spells. |
| Kih Rune | Enemies' Frozen debuffs now only have a 15% chance to be removed at the end of each turn. |
| Len Rune | Enemies' Poison debuffs now cause them to take 100% more damage from this debuff. |
| Lua Rune | Enemies' Snare debuffs now cause them to take damage over time based on 30% of the inflictor's Speed. |
| Name | Description |
| Mae Rune | Your creatures have +10% Intelligence. |
| Mav Rune | Your creatures deal 35% more damage to Sorcery creatures. |
| Mul Rune | Your creatures take 35% less damage from Sorcery creatures. |
| Nae Rune | You gain 25% more Essence from battles. |
| Nax Rune | Your creatures' Arcane buffs now also cause them to deal 35% more damage with spells. |
| Ner Rune | Your creatures' Invisible buffs now also cause them to take 90% less damage. |
| Nuy Rune | Your creatures' Multicast buffs now cause them to cast a spell 1 additional time. |
| Omi Rune | Your creatures' Ward buffs now also give them a 50% chance to avoid attacks. |
| Opa Rune | Enemies' Confused debuffs now have a 100% chance to cause them to target the wrong creature. |
| Qah Rune | Enemies' Silence debuffs now also cause their attacks to deal 50% less damage. |